Lavigne made her film debut in the animated film Over the Hedge, which is based on the comic strip of same name. She worked alongside William Shatner, Bruce Willis, Garry Shandling, Wanda Sykes, Nick Nolte and Steve Carell. She is also acting in the Richard Gere film The Flock, as the girlfriend of a crime suspect, and her third project was Fast Food Nation, based on her favorite book. Lavigne wrote and recorded a song titled “Keep Holding On” with Dr. Luke, for the Eragon film soundtrack; it was included on her third album, The Best Damn Thing. The song was released for digital download on November 28, and made its worldwide debut on radio on November 17. It reached the top spot on the Canadian top twenty.
 
 Lavigne made a cameo in the film Going the Distance and also appeared in an episode of Sabrina, the Teenage Witch, performing “Sk8er Boi” with her band.